When the Arizona Cardinals go for their first 4-0 start since 2012 on Sunday, the Los Angeles Rams, also undefeated, will be standing in their way.
The Rams have beaten the Cardinals eight times in a row, dating back to 2017, and Los Angeles is about a 4.5-point favorite with most Arizona sports betting apps.
The Cardinals and Rams will kick off from SoFi Stadium in Inglewood at 1:05 p.m. Arizona time Sunday, with FOX carrying the contest live nationally.
Sports betting in Arizona launched on Sept. 9, just in time for the start of the NFL season.
Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR) 21+ only. Please Gamble Responsibly. See http://BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.
Cardinals Sizable Underdogs
The Cardinals are not favored to win for the first time since Week 1, when they knocked off the Tennessee Titans on the road as 2.5-point underdogs in Arizona NFL betting.
Arizona is a 4.5-point underdog, according to DraftKings Arizona and FanDuel Arizona, while BetMGM Arizona has the Cardinals at +4 as of Thursday afternoon.
For those looking to make a moneyline play, DraftKings and FanDuel have the Cardinals at +175, while BetMGM has Arizona at +160.
Must be 21+ and physically present in AZ, CO, IL, IN, IA, KS, KY, LA, ME, MD, MA, MI, MO, NJ, NY, NC, OH, PA, TN, VA, WV, WY or Washington, DC. New users only. Must register using eligible promo code. Min. qualifying bet amount: $1. Tokens max. bet amount: $25 per token. Tokens bet max. add'l winnings: $2,500 per token. Token(s) expire 14 days after receipt. Not reissued for voided/pushed bets. Void where prohibited. See Caesars.com/promos for full terms. Know When To Stop Before You Start®. Gambling Problem? CO, IL, KY, MD, MI, MO, NJ, TN, VA, WV, WY, KS (Affiliated with Kansas Crossing Casino), ME (Licensed through the Mi’kmaq Nation, Penobscot Nation, and Houlton Band of Maliseet Indians, federally recognized tribes located in the State of Maine), NC (Licensed through Tribal Casino Gaming Enterprise), PA (Affiliated with Harrah's Philadelphia): If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) or MD: visit mdgamblinghelp.org or WV: visit 1800gambler.net; AZ: Call 1-800-NEXT-STEP; IN: Call 1-800-9-WITH-IT; IA: Call 1-800-BETSOFF; MA: Call 1-800-327-5050 or visit gamblinghelplinema.org, NY: Call 877-8-HOPENY or text HOPENY (467369); LA (Licensed through Horseshoe Bossier City and Caesars New Orleans) Call 1-800-522-4700, Washington, DC (OLG Class A licensed Operator): Call 1-800-MY-RESET. ©2026, Caesars Entertainment.
Rams Rolling at Home
A major reason for Arizona being a sizable underdog in Week 4 rests with the Rams’ performance at home this season.
In two home games, the Rams have outscored their opponents, 68-34, including a 10-point win against the defending champs on Sunday.
The Rams’ 34-24 victory over Tampa Bay saw veteran QB Matthew Stafford throw for 343 yards and four touchdowns, outgaining the Buccaneers, 446-407 offensively.
It was the latest strong performance turned in by the 13th-year QB, who’s averaging 314 passing yards per game this season.
Stafford, who was traded to Los Angeles for fellow No. 1 overall pick and QB Jared Goff during the offseason, currently ranks fourth in the NFL in passing yards (942) — just behind Cardinals QB, Kyler Murray, who has 1,005 yards this year.
The other threat that the Rams have offensively is wide receiver Cooper Kupp, who leads the NFL in receptions (25) and receiving yards (367), while tied atop the league in receiving touchdowns (5).
Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR) 21+ only. Please Gamble Responsibly. See http://BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.
Can’t Stop Kyler Murray
Murray currently is odds-on favorite to win the NFL MVP award in 2021 at DraftKings (+750) and BetMGM (+700) and is among the favorites at FanDuel (tied for fifth at +850).
That’s because the former Heisman Trophy winning QB currently ranks third in the NFL in passing yards (1,005) and is tied for fifth in passing touchdowns (7) in three games.
His three rushing touchdowns this season are tied for the league lead, along with Carolina Panthers QB Sam Darnold, Cleveland Browns RB Nick Chubb, Tennessee Titans RB Derrick Henry and Seattle Seahawks RB Chris Carson.
GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit http://gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit http://ccpg.org (CT), or visit http://www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/KY/NH/PR/WY). Void in NH/OR/ONT/PR. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new customer. Min. $5 first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Plus, upon qualifying bet placement, get 1 100% Profit Boost Token, valid only for a NCAA Tournament Winner bet. Max. Bet: $10. Profit Boost Tokens are single-use and expire on 4/6/26 at 11:59 PM ET. Must select Token BEFORE placing bet. Boost only applies to winnings. Ends 4/6/26 11:59 PM ET. Terms: https://sportsbook.draftkings.com/promos.
No Stopping the Rams
The Rams have had their way with the Cardinals of late, winning eight consecutive games against Arizona, five of which were decided by 10 points or more.
The Cardinals last beat Los Angeles on New Year’s Day 2017, when Arizona shellacked the Rams, 44-6.
Since then, the Cardinals have been outscored by L.A., 251-91, and have failed to score more than 10 points in five of those defeats.
Sunday’s game should feature a bit more scoring than we’ve seen in those games, with an over/under of 54.5 listed on BetMGM, DraftKings and FanDuel.
Whether the Cardinals can knock off the Rams for the first time in 1,737 days will rest on the ability of Murray and company to turn the tide against the Rams’ high-powered defense.
We’ll know whether they’re able to do that in the early afternoon hours of Sunday, under the bright lights of sunny Southern California.
Must be 21+ and present in AZ to participate. T&Cs apply.
Must be 21+ to participate. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, KY, MI, NJ, OH, PA, IL, TN, VA, VT), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), visit www.mdgamblinghelp.org (MD), 1-800-522-4700 (WY), or visit www.1800gambler.net (WV). GamblingHelpLineMA.org or call (800) 327-5050 for 24/7 support (MA). Call 1-877-8HOPE-NY or text HOPENY (467369) (NY).
Must be 21+ and physically present in AZ, CO, IL, IN, IA, KS, KY, LA, ME, MD, MA, MI, MO, NJ, NY, NC, OH, PA, TN, VA, WV, WY or Washington, DC. New users only. Must register using eligible promo code. Min. qualifying bet amount: $1. Tokens max. bet amount: $25 per token. Tokens bet max. add'l winnings: $2,500 per token. Token(s) expire 14 days after receipt. Not reissued for voided/pushed bets. Void where prohibited. See Caesars.com/promos for full terms. Know When To Stop Before You Start®. Gambling Problem? CO, IL, KY, MD, MI, MO, NJ, TN, VA, WV, WY, KS (Affiliated with Kansas Crossing Casino), ME (Licensed through the Mi’kmaq Nation, Penobscot Nation, and Houlton Band of Maliseet Indians, federally recognized tribes located in the State of Maine), NC (Licensed through Tribal Casino Gaming Enterprise), PA (Affiliated with Harrah's Philadelphia): If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) or MD: visit mdgamblinghelp.org or WV: visit 1800gambler.net; AZ: Call 1-800-NEXT-STEP; IN: Call 1-800-9-WITH-IT; IA: Call 1-800-BETSOFF; MA: Call 1-800-327-5050 or visit gamblinghelplinema.org, NY: Call 877-8-HOPENY or text HOPENY (467369); LA (Licensed through Horseshoe Bossier City and Caesars New Orleans) Call 1-800-522-4700, Washington, DC (OLG Class A licensed Operator): Call 1-800-MY-RESET. ©2026, Caesars Entertainment.
![quote quote]()