Latest Arizona Cardinals Super Bowl Odds: September 2025

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Kyler Murray and the Cardinals haven’t made the playoffs since 2021, but optimism is building in the Grand Canyon State after a 1-0 start to the 2025 season. With key upgrades from free agency and the draft, Arizona is aiming to turn things around and make a push for Super Bowl 60. They’ll host the Carolina Panthers on September 14 in their home opener.

Ahead of Week 2, the Arizona Cardinals are long shots to win the Super Bowl. We will be tracking Arizona's latest Super Bowl odds offered by some of the top Arizona sports betting operators all season long.

Cardinals' Super Bowl 60 Odds: September 13, 2025

The Cardinals' Super Bowl 60 odds are +5000 according to DraftKings Arizona. These odds will fluctuate throughout the season and differ across sportsbooks.

👑 Odds to Win Super Bowl 60+5000 (1.9% chance)
🏆 Odds to Win NFC+2200 (4.4% chance)
⭐ Odds to Win NFC West+350 (22.2% chance)
🔥 Odds to Make Playoffs-110 (52.4% chance)
❌ Odds to Miss Playoffs-110 (52.4% chance)
✅ Odds Last Updated:September 2025

Note that Arizona sports betting promos could improve your bankroll for some odds across other NFL teams. If you’re looking to get in on the NFL action, James Conner is -130 to score an anytime touchdown in Week 2.

21+. New customers in AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA, MA, MD, MI, NC, NJ, OH, PA, TN, VT, VA, WV, or WY. Must sign up by 9/30/25. Apply offer in bet slip; place $1+ American football cash wager w/ odds +300 or longer each Game Day. Wager must settle as loss to qualify for FanCash equal to the amount of losing wager (up to $100 FanCash per Game Day). Rewards expire 10/31/25. Terms, including FanCash terms apply-see Fanatics Sportsbook app. Gambling Problem? Call or Text 1-800-GAMBLER, 1-800-NEXT-STEP (AZ), 1-800-9-WITH-IT (IN), 1-888-532-3500 (VA).

Cardinals' Super Bowl Odds vs. NFC West

Right now, the Cardinals have the second-longest odds in the NFC West to win the Super Bowl. The San Francisco 49ers and Los Angeles Rams lead the division with the best Super Bowl 60 odds at +2200. Early in the season, Arizona faces back-to-back divisional tests that will be key indicators of their chances both within the division and in the race for Super Bowl 60. Week 3 brings a road trip to San Francisco, followed by a Week 4 home game against Seattle.

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Latest Updates Impacting Cardinals' Odds to Win SB LX

Throughout the season, the Cardinals’ Super Bowl odds will fluctuate based on player performance and injuries. Below, you’ll find the latest updates affecting those odds:

  • 🗓️ September 7: Arizona wins on the road against New Orleans, 20-13.
  • 🗓️ August 28: The Cardinals place DL Justin Jones on injured reserve.
  • 🗓️ August 26: Arizona place DLs Walter Noel III and Bilal Nichols, and LB BJ Ojulari on the PUP list.
  • 🗓️ August 7: The Cards sign OL Will Hernandez to a one-year contract.
  • 🗓️ June 10: DL Walter Nolen III signs a four-year contract with Arizona.
  • 🗓️ May 21: The Cardinals sign LB J.J. Russell to a one-year contract.
  • 🗓️ April 24: Arizona drafts DT Walter Nolen from Ole Miss in the first round of the 2025 draft. 
  • 🗓️ April 17: DE Calais Campbell signs with Arizona.
  • 🗓️ April 3: The Cardinals sign OL Jake Curhan and re-sign OL Kelvin Beachum.
  • 🗓️ April 3: Arizona signs TE Trey McBride to a four-year contract extension.

As Arizona makes more moves, this section will be updated. Check back regularly to stay informed on the major moves made by the Cardinals.

 

  • 🗓️ March 17: WR Zay Jones re-signs with Arizona.
  • 🗓️ March 12: The Cards sign OLB Josh Sweat, LB Akeem Davis-Gaither, DL Dalvin Tomlinson, and QB Jacoby Brissett.
  • 🗓️ March 7: Arizona re-signs LS Aaron Brewer to a one-year contract and S Joey Blount to a two-year contract.
  • 🗓️ January 5: The Cardinals finish the season with an 8-9 record after defeating the San Francisco 49ers in Week 18, 47-24.
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Kyler Murray throws the ball

Arizona Cardinals' 2025 Schedule

The Arizona Cardinals have one of the easiest schedules in the NFL based on last season’s strength of schedule, with their opponents combining for a .457 winning percentage. They’ll host the Carolina Panthers in Week 2 for their home opener and are listed as 6.5-point favorites at most sportsbooks.

 

Cardinals ScheduleLineResult
Week 1 at SaintsAZ -6.5, ML -298W 20-13
Week 2 vs PanthersAZ -6.5, ML -298TBD
Week 3 at 49ersAZ +3.5, ML +164TBD
Week 4 vs SeahawksAZ -2.5, ML -135TBD
Week 5 vs TitansAZ -5.5, ML -238TBD
Week 6 at ColtsAZ -1.5, ML -125TBD
Week 7 vs PackersAZ +1.5, ML +100TBD
Week 8 BYE--
Week 9 at CowboysAZ +1.5, ML +102TBD
Week 10 at SeahawksAZ +1.5, ML +100TBD
Week 11 vs 49ersAZ +1.5, ML +100TBD
Week 12 vs JaguarsAZ -3, ML -155TBD
Week 13 at BuccaneersAZ +3.5, ML +150TBD
Week 14 vs RamsAZ +1.5, ML -102TBD
Week 15 at TexansAZ +2.5, ML +110TBD
Week 16 vs FalconsAZ -3.5, ML -175TBD
Week 17 at BengalsAZ +3.5, ML -110TBD
Week 18 at RamsAZ +3.5, ML +145TBD
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Key Contributors Toward Cardinals Super Bowl Odds

The Cardinals' path to the playoffs starts, of course, with QB Kyler Murray, who showed consistency throughout the 2024 season with over 3,800 passing yards and 21 TDs. QB1 also rushed for over 500 yards, the most since the 2020 season. With a solid supporting cast, Murray has the potential to lead Arizona to the Super Bowl. 

McBride has proved to be a reliable target for Murray. He finished the season second in receiving yards among tight ends and was elected to his first Pro Bowl. Rookie wide receiver Marvin Harrison Jr. was Murray's second-most productive pass catcher behind McBride and finished the season with 62 receptions and eight touchdowns. Running back James Connor also had a strong year, rushing for a career-high 1,094 yards. The Cardinals have strengthened their offensive line by signing OLB Josh Sweat.

Arizona added a slew of talented players to its defense through free agency and the draft, including DL Calais Campbell and rookie DT Walter Nolen III. To top it off defensively, Budda Baker continues to be the leader fans come to expect. The veteran safety was second in the league with 95 solo tackles and was elected to his seventh consecutive Pro Bowl.

Cardinals Super Bowl Prediction and LX Outlook

Kyler Murray stayed healthy all season, helping Arizona stage a surprising resurgence in 2024. Despite that, the Cardinals still missed the playoffs and are now gearing up for the new season with an improved roster.

Arizona has been active this offseason, signing key free agents and bolstering its defense through the draft. Before the draft, the Cardinals’ Super Bowl odds sat at +7000. Following a strong draft, those odds have improved slightly to +5000. If things start clicking early, we could see the Cardinals’ odds improve even more.

Cardinals' 2025 Draft Class

Round 1 - DT Walter Nolen (Ole Miss)
Round 2 - CB Will Johnson (Michigan)
Round 3 - DT Jordan Burch (Oregon)
Round 4 - LB Cody Simon (Ohio State)
Round 5 - CB Denzel Burke (Ohio State)
Round 6 - OG Hayden Conner (Texas)
Round 7 - S Kitan Crawford (Nevada)

According to +122 odds at FanDuel, Arizona has a 45.1% chance of making the playoffs. For a closer look at the Cardinals' playoff chances, we have a separate article tracking Arizona's postseason picture.

Where Can I Bet on the Arizona Cardinals to Win the Super Bowl?

DraftKings, BetMGM, Caesars Sportsbook, and FanDuel are among the most trusted sportsbooks in the industry. Each currently lists odds for the Cardinals and each of the NFL’s 32 teams to win Super Bowl LX and more futures for the 2025 season.

In the state of Arizona, sports betting is legal, both online and at retail locations. Bettors must be at least 21 years old to legally wager on the Cardinals to win the Super Bowl or any other sports bet.

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Cardinals Super Bowl History

The Arizona Cardinals are the oldest franchise in the NFL, yet they’ve only made one Super Bowl appearance, Super Bowl XLIII against the Pittsburgh Steelers. battle filled with memorable moments, including Larry Fitzgerald’s spectacular 64-yard catch-and-run touchdown that gave the Cardinals the lead late in the game. But that highlight was overshadowed by a game-winning touchdown from Ben Roethlisberger to Santonio Holmes with less than a minute left.

Arizona got into range for a Hail Mary attempt, but Kurt Warner was sacked and lost a fumble to secure the 27-23 win for the Steelers. Adding salt to the wound, the following week, Fitzgerald came down with what was a similar pass to the one Warner would have thrown for a touchdown in the Pro Bowl. If only...

Have the Cardinals Ever Won the Super Bowl?

No. The Arizona Cardinals have never won the Super Bowl. They’re one of just 12 NFL teams to have never hoisted the Lombardi Trophy. The Cardinals played in Super Bowl XLIII, losing to the Pittsburgh Steelers in their only Super Bowl appearance. Despite a long history, the franchise is still chasing its first Super Bowl title.

How Many Times Have the Cardinals Won the Super Bowl?

Zero. Arizona has made one Super Bowl appearance and could not secure the Lombardi Trophy. Joining Arizona among teams to never win the Super Bowl are the Buffalo Bills, Houston Texans, Tennessee Titans, Jacksonville Jaguars, Cleveland Browns, Cincinnati Bengals, Los Angeles Chargers, Detroit Lions, Minnesota Vikings, Carolina Panthers, and Atlanta Falcons.

Have the Cardinals Ever Been to the Super Bowl?

Yes, the Arizona Cardinals have one Super Bowl appearance. In Super Bowl XLIII, the Cardinals fell to the Pittsburgh Steelers in Tampa, 27-23. Pittsburgh wide receiver Santonio Holmes was named the game’s MVP.

Other than the 2008-09 season, the closest the Cardinals have come to the Super Bowl is when they made the NFC Championship during the 2015-16 season. Arizona lost 49-15 to the Carolina Panthers and has yet to advance past the wild-card round since.

How Many Times Have the Cardinals Been to the NFC Championship Game?

The Cardinals have been to the NFC Championship Game just twice. They beat the Philadelphia Eagles at home to reach Super Bowl XLIII in the 2008-09 season and fell on the road to the Carolina Panthers 49-15 in a bid to reach Super Bowl 50.

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Arizona Cardinals' Super Bowl FAQs

Author

Wes Roesch

Wes is an editor and writer for BetArizona.com. Based out of the Kansas City area, Wes has covered sports professionally since 2015 with a strong emphasis on sports betting and the NFL, though he's also covered pro wrestling, UFC, college sports and more.

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