Cardinals Play First Home Monday Night Game of Arizona Sports Betting Era

Cardinals Play First Home Monday Night Game of Arizona Sports Betting Era

The Arizona Cardinals enter Week 14 of the NFL regular season with the league’s best record and a shot at vanquishing a divisional rival on national television.

The 10-2 Cardinals host the 8-4 Los Angeles Rams in the team’s first Monday Night Football contest since Arizona betting apps launched in September.

The game kicks off at 6:15 p.m. local time Monday on ESPN.

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Cardinals Favored to Beat Rams

Arizona sportsbooks are giving the Cardinals a slight edge over the Rams in the franchise’s 40th appearance on Monday Night Football.

Both DraftKings Sportsbook Arizona and FanDuel Sportsbook Arizona list the Cardinals at -2.5 as of Monday morning.

The oddsmakers at BetMGM Arizona, meanwhile, have Arizona at -3 (-105).

For those looking to place a moneyline wager, BetMGM Arizona has the Cardinals at -152, while DraftKings Sportsbook Arizona has them at -140, and FanDuel Sportsbook Arizona has the home team at -146.

All three sites list different over/unders, with BetMGM Arizona putting it at 52 total points (-110), while DraftKings Sportsbook Arizona pins it at 51.5 (-110), and FanDuel Sportsbook Arizona has the number at 52.5 (-110).

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Cardinals Gunning for Season Sweep of L.A.

The Cardinals had little trouble rolling past the Rams 37-20 at SoFi Stadium in L.A. when the two sides met in Week 4.

A win on Monday would give Arizona its first season sweep of the Rams since the 2014 season, when the Cardinals beat the then-St. Louis Rams, 31-14 and 12-6.

Since then, the Rams have enjoyed a 10-3 record against the Cardinals, including a pair of wins against Arizona in 2020.

One key for the Cardinals will be the play of quarterback Kyler Murray, who looked solid in his return to action against Chicago on Sunday.

Murray, who missed three games with an ankle injury, connected on 11-of-15 passes for 123 yards and two touchdowns in Arizona’s 33-22 road win over the Bears.

The former Heisman Trophy winner added 59 yards and two scores on the ground for Kliff Kingsbury’s team. Murray threw for 268 yards and two scores in the Cardinals’ Week 4 victory over the Rams.

Cardinals Super Bowl Odds Improve

The Cardinals’ Arizona Super Bowl betting odds received a shot in the arm Monday, with four sportsbooks elevating Arizona’s standing in the league.

Arizona’s odds went from +800 a week ago to +750 at BetMGM Arizona, ranking fourth in the NFL.

At Caesars Sportsbook Arizona, the Cardinals went from +1000 two weeks ago to +900 last week, and up to +800 on Monday, good for fourth in the league.

DraftKings Sportsbook also boosted the Cardinals from +900 to +800, giving the team the fifth-best odds to win Super Bowl LVI.

At FanDuel Sportsbook Arizona, the Cardinals are third overall at +750, one week after the operator listed them at +850.

The oddsmakers at TwinSpires Sportsbook Arizona put the Cardinals at +800, while Unibet Arizona bumped them to +800, with the franchise ranking fourth overall in championship Arizona NFL betting odds on both sites.

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NFC West Race Hinges on Monday’s Game

A win over the Rams on Monday would give Arizona a three-game lead over the Rams in the NFC West with four games to play — virtually locking up a division crown for the Cardinals.

The Cardinals last won their division in 2015 when Arizona went 13-3 under then-head coach Bruce Arians, before losing to the Seattle Seahawks in the NFC Championship Game.

Arizona also has a one-game lead over the Green Bay Packers and Tampa Bay Buccaneers for the top seed in the NFC playoffs and a first-round bye in the playoffs. The Packers hold a head-to-head tiebreaker over the Cardinals thanks to a 24-21 win in Glendale earlier this season.



Christopher Boan

Christopher Boan is the lead writer at after covering sports and sports betting in Arizona for more than seven years, including stops at, the Tucson Weekly and the Green Valley News.

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