👇 Cardinals vs. Bills Odds: Quick Facts 👇
Here are the most important facts related to odds for the AZ vs. BUF Week 1 matchup:
| ⭐ Favorite | Buffalo Bills |
| 🔢 Point Spread | Cardinals +6.5, Bills -6.5 |
| 📊 Moneyline | Cardinals +240, Bills -298 |
| 📈 Game Total | Over/under 47 points |
| ✅ Last Verified | January 28, 2026 |
Odds via DraftKings AZ Sportsbook.
Who Is Favored to Win?
The Bills are favored to beat the Cardinals in Week 1. The lines suggest the Bills will win by 7 or more points, making the Cardinals a long underdog.
What's the Point Spread?
The point spread for Cardinals vs. Bills in Week 1 is Bills -6.5. The Bills are unsurprisingly heavy favorites after making the playoffs last season, while the Cards finished near the bottom of the league at 4-13.
What's the Moneyline?
The moneyline for Cardinals vs. Bills is set at AZ +240 and BUF -298. Betting $100 on +240 would earn $240 plus your $100 back if the Cards win. Meanwhile, betting $100 on the Bills would earn you just $33.56 plus your $100 back if the Bills win straight up.
What's the Over/Under?
The game total for the Cardinals and Bills Week 1 game is set at over/under 47 points. This suggests a slightly above average scoring game with each team in the low 20s.
Related Cardinals Betting Content:
Arizona Cardinals Chances to Win vs. Buffalo Bills
The Cardinals have a 28.20% chance to beat the Bills. Their chances are calculated using implied probability based on odds from DraftKings. Here is how it is calculated for each team using +240 odds for the Cards and -298 odds for the Bills:
Cardinals chances: 100 ÷ (240 + 100) * 100 = 29.41%
Bills chances: 298 ÷ (298 + 100) * 100 = 74.87%
However, the above percentages add up to 104.28%. This is due to the vig, which is the house edge for the sportsbook which allows them to profit off the bet. To remove the vig, we simply divide each team's chance by 104.25.
Cardinals chances (after vig): 29.41 ÷ 104.28 = 28.20%
Bills chances (after vig): 74.87 ÷ 104.28 = 71.80%
Note that both of the final team chances above finally equal 100%. Hence, the 28.20% chance to win for the Cardinals.
How Arizona Wins vs. Buffalo
The Cardinals will have to bring their A-game in order to win this one. The Bills were strong Super Bowl contenders last year, getting knocked off by Super Bowl champion Kansas City Chiefs, and are expected to be a contender again this season. The Cardinals, meanwhile, are returning quarterback Kyler Murray who was injured much of last season. Arizona will need a flawless performance from Murray in this one to have a chance.
Other Cardinals Matchups This Season:
How Buffalo Wins vs. Arizona
The Bills will need to be themselves in order to win this one. Quarterback Josh Allen is one of the best signal-callers in the league and should be able to put together a great performance in Week 1 in front of his home crowd, even if he lost his top weapon in receiver Stefon Diggs during the offseason. The key to this game will be to play mistake-free football and not allow Arizona to take advantage of any miscues.
How to Watch the Game
AZ vs. BUF will air on CBS in local markets at noon CT. Out-of-market fans can catch the game on NFL Sunday Ticket, which is exclusively on YouTube TV. Check 506sports.com to see if you get the game in your local market.
Exclusive Promos for Betting on the Game
There are plenty of Arizona sports betting promos available to use for the Cardinals vs. Bills matchup. These promos can also be used on props, futures and other bets:
History of Cardinals vs. Bills
The Cardinals and Bills have played each other just 12 times dating back to 1971, all the way back when the Cardinals were named the St. Louis Cardinals.
Record All-Time
The Bills lead the all-time series over the Cardinals 7-5, winning two of the last three matchups.
Most Recent Matchup
The last game between the Cardinals and Bills was played on November 15, 2020. Kyler Murray led the Cards to a 32-30 victory against Josh Allen, coming back after being down 23-9 earlier in the game and winning on a 43-yard Hail Mary touchdown pass to then-Cards WR DeAndre Hopkins.
Top Games
| Date | Matchup | Winner |
|---|---|---|
| Nov. 15, 2020 | BUF @ AZ | Cardinals 32-30 |
| Oct. 14, 2012 | BUF @ AZ | Bills 19-16 |
FAQs
The Bills are 6.5-point favorites over the Cardinals in Week 1.
The over/under for Cardinals vs. Bills in Week 1 is 47 points.
You can place bets on the Cardinals vs. Bills at any legal sportsbook in Arizona. You just have to be 21 or older, within state lines and signed up for an account on your chosen betting app. Don't forget to use a promo to maximize your earnings.
The Cardinals and Bills play in Week 1 of the 2024 NFL season on Sunday, September 8 at 1 p.m. ET/10 a.m. PT.
Cardinals vs. Bills will be aired live on CBS in local markets. Out-of-market viewers can get NFL Sunday Ticket on YouTube TV. Check 506sports.com to see if you'll get the game in your local market.
Author
Calli is lifelong resident of Arizona and has been an avid sports fan since she can remember. After earning her Bachelor’s degrees from the Walter Cronkite School of Journalism at Arizona State University, she combined her passion for journalism and sports. Calli has covered the NFL, NBA, MLB, NCAAF, college sports, and sports betting for several media outlets.
