Cardinals vs. 49ers Odds: Arizona Is Underdog Week 5 Against San Francisco

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Key Takeaways:

  • ๐Ÿ† Favorite: The Cardinals are underdogs against the 49ers in Week 5.
  • ๐Ÿ’ช Cardinals' Chances: Arizona has a 25.23% chance to beat the Niners.
  • ๐Ÿ‘€ Point Spread: The Cardinals are +7.5 vs. the 49ers.
  • ๐Ÿ“ Over/Under: The over/under for Cardinals vs. 49ers is set at 50 points.
  • ๐Ÿ’ฒ Moneyline: The Cardinals' moneyline is +280, while the 49ers' is -355.

The Arizona Cardinals will play NFC West rival San Francisco 49ers two times in 2024. The first matchup in Week 5 will be in San Francisco on a Sunday at 1:05 p.m. PT, while the Cardinals will be at home for the Week 18 game which will either be on a Saturday or Sunday.

Here you'll find the best odds and lines for Cardinals vs. 49ers found at Arizona sportsbooks.

๐Ÿ‘‡ Cardinals vs. 49ers Odds: Quick Facts ๐Ÿ‘‡

Here are the most important facts related to odds for AZ vs. SF:

โญ FavoriteSan Francisco 49ers
๐Ÿ”ข Point SpreadCardinals +7.5, 49ers -7.5
๐Ÿ“Š MoneylineCardinals +280, 49ers -355
๐Ÿ“ˆ Game TotalOver/under 50 points
โœ… Last VerifiedDecember 9, 2024

Odds via DraftKings Sportsbook.

Who Is Favored to Win?

The San Francisco 49ers are favored to beat the Cardinals in both their Week 5 and Week 18 matchups. That could always change as the season progresses, so you'll want to keep an eye on the line if you're thinking about betting on it.

What's the Point Spread?

The point spread for Cardinals vs. 49ers in Week 5 is 49ers -7.5, Cardinals +7.5. This makes the 49ers heavy favorites, which is expected considering they are the defending NFC champions.

What's the Moneyline?

The moneyline for Cardinals vs. 49ers is set at AZ +280 and SF -355. Betting $100 on +280 would earn $280 plus your $100 back if the Cards win. Meanwhile, betting $100 on the Niners would earn you just $28.17 plus your $100 back if the 49ers win straight up.

What's the Over/Under?

The game total for the Cardinals and 49ers Week 5 game is set at over/under 50 points. This suggests an average to high scoring game between the two, with each teams scoring in the 20s.


Related Cardinals Betting Content:


Arizona Cardinals Chances to Win vs. San Francisco 49ers

The Cardinals have a 25.23% chance to beat the 49ers in Week 5. Their chances are calculated using implied probability based on odds from DraftKings. Here is how it is calculated for each team using +280 odds for the Cardinals and -355 odds for the 49ers:

Cardinals chances: 100 รท (280 + 100) * 100 = 26.32%
49ers chances: 355 รท (355 + 100) * 100 = 78.02%

However, the above percentages add up to 104.34%. This is due to the vig, which is the house edge for the sportsbook which allows them to profit off the bet. To remove the vig, we simply divide each team's chance by 104.34.

Cardinals chances (after vig): 26.32 รท 104.34 = 25.23%
49ers chances (after vig): 78.02 รท 104.34 = 74.77%

Note that both of the final team chances above finally equal 100%. Hence, the 25.23% chance to win for the Cardinals.

How Arizona Wins vs. San Francisco

This one will mainly hinge on Cardinals quarterback Kyler Murray's ability. He has played well so far this season, establishing a solid rapport with rookie receiver Marvin Harrison Jr. who is the team's leading receiver. However, the Niners pose a tough challenge that will be difficult for Arizona to overcome.


Other Cardinals Matchups This Season:


How San Francisco Wins vs. Arizona

The 49ers made the Super Bowl last year and barely lost to the Kansas City Chiefs in overtime. They'll be looking to get back to the big game, which means they should have one of the NFL's best squads again in 2024. To win this one, the Niners will simply need to play mistake-free football and make sure Arizona doesn't capitalize on any errors they may make.

How to Watch Cardinals vs. 49ers

The Cardinals vs. 49ers Week 5 game will air on FOX in local markets at 1:05 p.m. PT. Out-of-market fans can catch the game on NFL Sunday Ticket, which is exclusively on YouTube TV. Check 506sports.com to see if you get the game in your local market.

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Best Prop Picks for Cardinals vs. 49ers

The widget below uses predictive analytics and projections to find potential betting edges. Be sure to do your own research before making any wagers.

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San Francisco 49ers quarterback Brock Purdy shakes hands with Arizona Cardinals quarterback Kyler Murray

History of Cardinals vs. 49ers

The Cardinals and 49ers have played each other 65 times dating way back to 1951 when the Cardinals were called the Chicago Cardinals (and later St. Louis Cardinals, then later Phoenix Cardinals before becoming the Arizona Cardinals).

Record All-Time

The 49ers lead the all-time series 36-29 over the Cardinals, and have won each of the last four matchups between the two.

Most Recent Matchup

The last game between the Cardinals and Niners was played on December 17, 2023. The 49ers won that game 45-29 with QB Brock Purdy throwing for four touchdowns.

Top 5 Games

DateMatchupWinner
Oct. 31, 2019SF @ AZ49ers 28-25
Nov. 25, 2007SF @ AZ49ers 37-31
Dec. 12, 2004SF @ AZ49ers 31-28
Oct. 10, 2004AZ @ SF49ers 31-28
Nov. 6, 1988SF @ PHXCardinals 24-23

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Author

Wes Roesch

Wes is an editor and writer for BetArizona.com. Based out of the Kansas City area, Wes has covered sports professionally since 2015 with a strong emphasis on sports betting and the NFL, though he's also covered pro wrestling, UFC, college sports and more.

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