👇 Cardinals vs. 49ers Odds: Quick Facts 👇
Below are the latest odds for the Week 11 Cardinals vs 49ers matchup. Expect movement before kickoff, as lines often vary across sportsbooks.
| ⭐ Favorite | San Francisco 49ers |
| 🔢 Point Spread | Cardinals +3, 49ers -3 |
| 📊 Moneyline | Cardinals +145, 49ers -175 |
| 📈 Game Total | Over/under 48.5 points (-108, -112) |
| ✅ Last Verified | November 26, 2025 |
Odds via DraftKings Sportsbook.
Who Is Favored to Win?
The San Francisco 49ers are favored in Week 11, coming off an earlier win over the Cardinals and holding a stronger record. QB Brock Purdy and WR Ricky Pearsall return for the 49ers, giving them a boost on offense. Still, Arizona has a real chance to pull off the upset if they lean on TE McBride, who creates mismatches against San Francisco’s linebackers and thrives even against double teams.
What's the Point Spread?
The Week 11 point spread for Cardinals vs 49ers is currently San Francisco -3 and Arizona +3. Depending on any injury news, these odds could shift leading up to kickoff. Bettors will want to monitor the final injury reports closely, as the availability of key players on either side could have a big impact on the line.
What's the Moneyline?
The moneyline for Cardinals vs 49ers is set at AZ +145 and SF -175. Betting $100 on -175 would earn $57.14 plus your $100 back if the Niners win. Meanwhile, betting $100 on the Cards would earn you $145 plus your $100 back if Arizona wins straight up.
What's the Over/Under?
The total for the Cardinals vs 49ers Week 11 game is set at 48.5 points. Last season, the teams combined for 47 points in their first matchup and 71 in the season finale. In Week 3, they combined for just 29 points, but a higher-scoring affair is expected this time around.
Related Cardinals Betting Content:
Arizona Cardinals Chances to Win vs San Francisco 49ers
The Cardinals have a 39.1% chance to beat the 49ers in Week 11. Their chances are calculated using implied probability based on odds from DraftKings. Here is how it is calculated for each team using +145 odds for the Cardinals and -175 odds for the 49ers:
Cardinals chances: 145 ÷ (145 + 100) * 100 = 40.8%
49ers chances: 175 ÷ (175 + 100) * 100 = 63.6%
However, the above percentages add up to 104.4%. This is due to the vig, which is the house edge for the sportsbook which allows them to profit off the bet. To remove the vig, we simply divide each team's chance by 104.4.
Cardinals chances (after vig): 40.8 ÷ 104.4 = 39.1%
49ers chances (after vig): 63.6 ÷ 104.4 = 60.9%
Note that both of the final team chances above finally equal 100%. Hence, the 39.1% chance to win for the Cardinals.
How Arizona Wins vs San Francisco
To beat the 49ers, the Cardinals need a strong defensive showing, especially a consistent pass rush to pressure Brock Purdy, who is returning from injury. On offense, they’ll need big plays from stars like Trey McBride and Michael Wilson, along with a dynamic performance from Jacoby Brissett to keep San Francisco’s defense off balance.
Other Cardinals Matchups This Season:
How San Francisco Wins vs Arizona
The 49ers can beat the Cardinals by establishing a strong run game, using players like Christian McCaffrey to exploit gaps in Arizona’s defensive front. Consistent pressure on Jacoby Brissett will disrupt the passing game, while protecting the ball and minimizing turnovers will be key in a high-stakes divisional matchup.
How to Watch Cardinals vs 49ers
The Cardinals vs 49ers Week 11 game airs on FOX in local markets at 2:25 p.m. MST on Sunday, November 16. Out-of-market viewers can watch via NFL Sunday Ticket, available exclusively on YouTube TV. Live TV streaming services, including YouTube TV, Hulu + Live TV, Fubo, and DIRECTV STREAM, also carry local FOX channels.
Exclusive Promos for Betting on the Game
There are many Arizona sports betting promos available to use for the Cardinals vs 49ers game. These promos can also be used on props, futures and other bets:
Best Prop Picks for Cardinals vs 49ers
The widget below highlights popular Cardinals vs. 49ers prop bets, including anytime touchdown scorers. Always do your own research before placing any wagers.
History of Cardinals vs. 49ers
The Cardinals and 49ers have played each other 68 times dating way back to 1951 when the Cardinals were called the Chicago Cardinals (and later St. Louis Cardinals, then later Phoenix Cardinals before becoming the Arizona Cardinals).
Record All-Time
The 49ers lead the all-time series 37-31 over the Cardinals and were on a four-game winning streak before losing to Arizona early in the 2024 season. San Francisco bounced back with the most recent win in Week 3.
Most Recent Matchup
The last meeting between the Cardinals and 49ers took place on September 21, 2025, at Levi's Stadium in California. The Cardinals lost 16-15, with QB Kyler Murray throwing for 159 yards and tight end Trey McBride hauling in a touchdown.
Top 5 Games
| Date | Matchup | Winner |
|---|---|---|
| Oct. 31, 2019 | SF @ AZ | 49ers 28-25 |
| Nov. 25, 2007 | SF @ AZ | 49ers 37-31 |
| Dec. 12, 2004 | SF @ AZ | 49ers 31-28 |
| Oct. 10, 2004 | AZ @ SF | 49ers 31-28 |
| Nov. 6, 1988 | SF @ PHX | Cardinals 24-23 |
FAQs
Sportsbooks have the San Francisco 49ers as 3-point favorites over the Arizona Cardinals for the Week 11 matchup. Keep an eye on the lines, as they could move before kickoff depending on injuries or other news throughout the week.
The over/under for the Cardinals vs. 49ers Week 11 matchup is set at 48.5 points, and we don’t expect this number to move much before kickoff. Last year, the two teams combined for 47 points in their first meeting and 71 in their season finale. In Week 3, however, they only combined for 29 points.
You can place bets on the Cardinals vs 49ers at any legal sportsbook in Arizona. You just need to be 21 or older, located within state lines, and have an account with your chosen betting app. Don’t forget to take advantage of promos to maximize your potential winnings.
The Cardinals and 49ers meet in Week 11 on Sunday, November 16, at State Farm Stadium in Arizona, with kickoff set for 2:25 p.m. MST. They faced each other in Week 3, with San Francisco taking the win.
The Cardinals vs 49ers Week 11 game will air live on FOX in local markets. Out-of-market viewers can watch via NFL Sunday Ticket on YouTube TV. Check 506sports.com to see if the game is available in your area.
Author
Wes is an editor and writer for BetArizona.com. Based out of the Kansas City area, Wes has covered sports professionally since 2015 with a strong emphasis on sports betting and the NFL, though he's also covered pro wrestling, UFC, college sports and more.
