👇 Cardinals vs. Seahawks Odds: Quick Facts 👇
Here are the most important facts related to odds for the AZ vs. SEA Week 4 TNF matchup:
| ⭐ Favorite | Arizona Cardinals |
| 🔢 Point Spread | Cardinals -1.5, Seahawks +1.5 |
| 📊 Moneyline | Cardinals -115, Seahawks -105 |
| 📈 Game Total | Over/under 43.5 points |
| ✅ Last Verified | October 17, 2025 |
Odds via DraftKings Sportsbook.
Who Is Favored to Win?
The Arizona Cardinals are favored to beat the Seattle Seahawks in Week 14. The Cards are 6-6 heading into this game while Seattle leads the division at 7-5.
What's the Point Spread?
The point spread for Cardinals vs. Seahawks in Week 4 is Cardinals -1.5, Seahawks +2.5. The small point spread suggests these two are closely matched, with Arizona getting the edge for being the home team.
What's the Moneyline?
The moneyline for Cardinals vs Seahawks is nearly even, with AZ -115 and SEA -105. Betting $100 on -115 would earn $86.96 plus your $100 back if the Cards win. Meanwhile, betting $100 on the Seahawks would earn you $95.24 plus your $100 back if the Seahawks win straight up.
What's the Over/Under?
The game total for the Cardinals and Seahawks Week 4 TNF game is set at over/under 43.5 points. This suggests an average-scoring game, with each team expected to score in the low 20s. The last time these two met, the combined total reached 48 points.
Related Cardinals Betting Content:
Arizona Cardinals Chances to Win vs Seattle Seahawks
The Cardinals have a 51.1% chance to beat the Seahawks in Week 4. Their chances are calculated using implied probability based on odds from DraftKings. Here is how it is calculated for each team using -115 odds for the Cardinals and -105 odds for the Seahawks:
Cardinals chances: 115 ÷ (115 + 100) * 100 = 53.5%
Seahawks chances: 105 ÷ (105 + 100) * 100 = 51.2%
However, the above percentages add up to 104.7%. This is due to the vig, which is the house edge for the sportsbook which allows them to profit off the bet. To remove the vig, we simply divide each team's chance by 104.7.
Cardinals chances (after vig): 53.5 ÷ 104.7 = 51.1%
Seahawks chances (after vig): 51.2 ÷ 104.7 = 48.9%
Note that both of the final team chances above finally equal 100%. Hence, the 51.1% chance to win for the Cardinals.
How Arizona Wins vs Seattle
This is a tricky game for the Cardinals, coming off a loss to NFC West rivals 49ers. The Cardinals’ defensive line is one of their biggest strengths this season, giving them the talent to pressure Seattle’s vulnerable offensive front. On offense, RB James Conner might be out for the season, but that won’t stop the Cardinals’ rushing attack. Kyler Murray has showcased his dual-threat ability, creating plays with his legs. His improvisational runs keep defenses off balance and could be enough to give Arizona the win.
Other Cardinals Matchups This Season:
How Seattle Wins vs Arizona
The Seahawks’ defense and recent dominance in the rivalry give Seattle an edge over the Cardinals. If the Hawks’ secondary remains fast and aggressive and the offense can overcome Arizona’s challenging pass rush, they have a strong chance for victory.
How to Watch Cardinals vs Seahawks
The Cardinals vs Seahawks Week 4 game will air on Amazon Prime as the Thursday Night Football matchup of the week. You can also stream the game on Fubo TV, NFL+ (in-market only), and YouTube TV with the NFL Sunday Ticket add-on.
Exclusive Promos for Betting on the Game
There are a handful of Arizona sports betting promos available to use on the Cardinals vs Seahawks Week 4 TNF game. These promos can also be used on props, futures and other bets:
History of Cardinals vs Seahawks
The Cardinals and Seahawks have played each other 52 times dating way back to 1976 when the Cardinals were called the St. Louis Cardinals (and later Phoenix Cardinals before becoming the Arizona Cardinals).
Record All-Time
The Seahawks lead the all-time series 29-22-1 over the Cardinals, with Arizona’s last win coming in November 2021.
Most Recent Matchup
The last game between the Cardinals and Seahawks took place in Week 14 of last season, with Seattle winning 30-18. The Seahawks also won their first matchup against Arizona last season, 16-6 in Week 12. In fact, Seattle has won the last seven meetings against the Cardinals.
Top 5 Games
The Arizona Cardinals and Seattle Seahawks have faced each other 52 times since 1976. Below, we’ve highlighted the top five matchups between these two NFC West rivals.
| Date | Matchup | Winner |
|---|---|---|
| Jan. 7, 2024 | SEA @ AZ | Seahawks 21-20 |
| Oct. 25, 2020 | SEA @ AZ | Cardinals 37-34 |
| Dec. 30, 2018 | AZ @ SEA | Seahawks 27-24 |
| Sept. 30, 2018 | SEA @ AZ | Seahawks 20-17 |
| Dec. 19, 1993 | PHX @ SEA | Cardinals 30-27 |
FAQs
The Arizona Cardinals are 1.5-point favorites over the Seattle Seahawks in their Week 4 matchup. This is likely due to home-field advantage, but a close game is expected between these two NFC West rivals. Both teams are 2-1, making this early-season matchup important for the division standings.
Before kickoff, the over/under for the Cardinals vs Seahawks Week 4 Thursday Night Football matchup is set at 43.5 points. This suggests sportsbooks expect a moderately scoring game, with both teams likely putting up points in the low 20s.
You can place bets on the Cardinals vs Seahawks at any legal sportsbook in Arizona. You must be 21 or older, within state lines, and have an account with your chosen betting app. Using a promo can help maximize your potential earnings.
The Arizona Cardinals and Seattle Seahawks will meet for the first time in Week 4 on Thursday Night Football, September 25. The game takes place in Glendale, Arizona, at State Farm Stadium, with kickoff scheduled for 8:15 p.m. EDT. They will meet again in Week 10.
The Cardinals vs Seahawks Week 4 game will be played on September 25 as part of Thursday Night Football and will air on Amazon Prime Video. You can also stream the game on Fubo TV, NFL+ (in-market only), and YouTube TV with the NFL Sunday Ticket add-on.
Author
Wes is an editor and writer for BetArizona.com. Based out of the Kansas City area, Wes has covered sports professionally since 2015 with a strong emphasis on sports betting and the NFL, though he's also covered pro wrestling, UFC, college sports and more.
