👇 Cardinals vs Seahawks Odds: Quick Facts 👇
Here are the most important facts related to odds for the AZ vs SEA Week 10 matchup:
| ⭐ Favorite | Seattle Seahawks |
| 🔢 Point Spread | Cardinals +6.5, Seahawks -6.5 |
| 📊 Moneyline | Cardinals +245, Seahawks -305 |
| 📈 Game Total | Over/under 45.5 points |
| ✅ Last Verified | November 5, 2025 |
Odds via DraftKings Sportsbook.
Who Is Favored to Win?
The Seattle Seahawks are favored to beat the Arizona Cardinals at home in Week 10. The Cards are 3-5 heading into this game while Seattle leads the division at 6-2.
What's the Point Spread?
The point spread for Cardinals vs Seahawks in Week 10 is Cardinals +6.5, Seahawks -6.5. With a better overall record and playing at home in Seattle, the Seahawks are 6.5-point favorites.
What's the Moneyline?
The moneyline for Cardinals vs Seahawks have the Cards as underdogs with AZ at +245 and SEA at -305. Betting $100 on +245 would earn $245 plus your $100 back if the Cards win. Meanwhile, betting $100 on the Seahawks would earn you $32.79 plus your $100 back if the Seahawks win straight up.
What's the Over/Under?
The game total for the Cardinals and Seahawks Week 10 game is set at over/under 45.5 points. This suggests an average-scoring game, with each team expected to score in the mid 20s. The last time these two met, the combined total reached 43 points.
Related Cardinals Betting Content:
Arizona Cardinals Chances to Win vs Seattle Seahawks
The Cardinals have a 29.3% chance to beat the Seahawks in Week 10. Their chances are calculated using implied probability based on odds from DraftKings. Here is how it is calculated for each team using +245 odds for the Cardinals and -305 odds for the Seahawks:
Cardinals chances: 100 ÷ (245 - 100) * 100 = 31.1%
Seahawks chances: 305 ÷ (305 + 100) * 100 = 75.3%
However, the above percentages add up to 106.4%. This is due to the vig, which is the house edge for the sportsbook which allows them to profit off the bet. To remove the vig, we simply divide each team's chance by 106.4.
Cardinals chances (after vig): 31.1 ÷ 106.4 = 29.2%
Seahawks chances (after vig): 75.3 ÷ 106.4 = 70.8%
Note that both of the final team chances above finally equal 100%. Hence, the 29.3% chance to win for the Cardinals.
How Arizona Wins vs Seattle
For Arizona to secure a win, the Cardinals need consistent offensive production from top playmakers like Marvin Harrison Jr. and Trey McBride, no matter who is at QB. On defense, they’ll need to replicate the performance that carried them to victory in Dallas. The Cardinals’ pass rush and cornerbacks, including players like Josh Sweat, must generate pressure on Sam Darnold while limiting big plays to Smith-Njigba and the Seahawks’ other receivers.
Other Cardinals Matchups This Season:
How Seattle Wins vs Arizona
For Seattle to come away with a win over Arizona, several factors will come into play. Lumen Field provides a raucous home environment that gives the Seahawks a clear advantage. Maintaining solid pass protection for Sam Darnold while creating running lanes for Kenneth Walker III and Zach Charbonnet will be key. Seattle will also want to exploit any weaknesses in Arizona’s roster, especially in the secondary or at running back.
How to Watch Cardinals vs Seahawks
The Cardinals vs Seahawks Week 10 game will air on CBS. You can also stream the game on Fubo TV, NFL+ (in-market only), and YouTube TV with the NFL Sunday Ticket add-on.
Exclusive Promos for Betting on the Game
There are a handful of Arizona sports betting promos available to use on the Cardinals vs Seahawks Week 10 game. These promos can also be used on props, futures and other bets:
History of Cardinals vs Seahawks
The Cardinals and Seahawks have played each other 53 times dating way back to 1976 when the Cardinals were called the St. Louis Cardinals (and later Phoenix Cardinals before becoming the Arizona Cardinals).
Record All-Time
The Seahawks lead the all-time series 30-22-1 over the Cardinals, with Arizona’s last win coming in November 2021.
Most Recent Matchup
The last game between the Cardinals and Seahawks took place in Week 4, with Seattle winning 23-20. The Seahawks also won both matchups against Arizona last season. In fact, Seattle has won the last eight meetings against the Cardinals.
Top 5 Games
The Arizona Cardinals and Seattle Seahawks have faced each other 53 times since 1976. Below, we’ve highlighted the top five matchups between these two NFC West rivals.
| Date | Matchup | Winner |
|---|---|---|
| Jan. 7, 2024 | SEA @ AZ | Seahawks 21-20 |
| Oct. 25, 2020 | SEA @ AZ | Cardinals 37-34 |
| Dec. 30, 2018 | AZ @ SEA | Seahawks 27-24 |
| Sept. 30, 2018 | SEA @ AZ | Seahawks 20-17 |
| Dec. 19, 1993 | PHX @ SEA | Cardinals 30-27 |
FAQs
The Seattle Seahawks are 6.5-point favorites over the Arizona Cardinals in their Week 10 matchup. This is likely due to home-field advantage, but a close game could still happen between these two NFC West rivals. The Hawks sit atop the division, while the Cardinals sit at the bottom.
Before kickoff, the over/under for the Cardinals vs Seahawks Week 10 matchup is set at 45.5 points. This indicates sportsbooks expect a moderately scoring game, with both teams likely putting up points in the mid-20s. For reference, the total in their Week 4 matchup was 43.
You can place bets on the Cardinals vs Seahawks at any legal sportsbook in Arizona. You must be 21 or older, within state lines, and have an account with your chosen betting app. Using a promo can help maximize your potential earnings.
The Arizona Cardinals and Seattle Seahawks will meet for the second time this season in Week 10 on November 8. The game takes place in Seattle, Washington at Lumen Field, with kickoff scheduled for 4:05 p.m. EDT.
The Cardinals vs. Seahawks Week 10 game will be played on November 8 as part of the late Sunday window and will air on CBS. Fans can also stream the game on FuboTV, NFL+ (in-market only), and YouTube TV with the NFL Sunday Ticket add-on.
Author
Wes is an editor and writer for BetArizona.com. Based out of the Kansas City area, Wes has covered sports professionally since 2015 with a strong emphasis on sports betting and the NFL, though he's also covered pro wrestling, UFC, college sports and more.
