Latest Arizona Cardinals Injury Report: Week 11 Update

Latest Cardinals Injury Report: November 11, 2025

Kyler Murray was hoping to make his return in Week 9, but after missing the game, he is now on IR. Head coach Jonathan Gannon confirmed that Jacoby Brissett will continue to be the starter moving forward. Brissett and the Cards fell to the Seahawks in Week 10 and will look to bounce back at home against the 49ers in Week 11.

Below is the latest Arizona Cardinals injury report:

Some Arizona sports betting apps will update you on a player’s injury status, but it’s always smart to double-check before placing any bets. Staying informed can give you a real edge when betting on Cardinals games this season.

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List of Notable Arizona Cardinals 2025 Injuries

As noted above, QB Kyler Murray is now on IR, joining RB James Conner, TE Tip Reiman, and others. WR Zay Jones was also just placed on IR. Rookie Walter Nolen III made his first NFL start in Week 9, delivering an impressive performance with four tackles, a sack, and a pass defensed.

For the upcoming matchup against the 49ers, a slew of players are questionable, including CB Max Melton, RB Bam Knight, CB Will Johnson, and DT Walter Nolen.

QB Brock Purdy could return for the 49ers, along with WR Ricky Pearsall. We’ll know more about each team’s injury report closer to the game.

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Wes Roesch

Editor & Writer

@WesRoesch

Wes is an editor and writer for BetArizona.com. Based out of the Kansas City area, Wes has covered sports professionally since 2015 with a strong emphasis on sports betting and the NFL, though he's also covered pro wrestling, UFC, college sports and more.